Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 9.93B 8.51B 7.96B 7.28B 13.73B 951B 13.88B 94.18B 36.62B 477B 37.28B 36.47B 1,579B P/E 2026 *
-16.4x
P/E 2027 * -31.6x
Enterprise Value 9.82B 8.42B 7.88B 7.2B 13.59B 941B 13.73B 93.21B 36.24B 472B 36.89B 36.09B 1,563B EV / Sales 2026 *
10.8x
EV / Sales 2027 * 7.12x
Free-Float
99.05%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 9.93B
-0.74%+3.78%+2.62%+23.10% 51.61B
+0.97%-0.49%+491.42%+562.98% 44.89B
-0.06%+7.56%+38.00%+20.40% 42.77B
-0.89%+2.37%+20.24%+86.59% 42.58B
+0.88%-3.48%+17.20%+57.20% 31.82B
-0.52%+3.34%+32.18%+144.06% 17.33B
-0.56%+1.58% - - 16.63B
+0.58%+4.66%+9.77%+30.87% 14.76B
+0.01%+2.86%+79.67%+48.45% 14.09B
Average +0.05%+4.83%+86.39%+121.71% 30.72B
Weighted average by Cap. -0.10%+5.13%+104.13%+140.40%

Financials

2026 *2027 *
Net sales 913M 783M 732M 670M 1.26B 87.46B 1.28B 8.67B 3.37B 43.92B 3.43B 3.36B 145B 1.4B 1.2B 1.12B 1.03B 1.94B 134B 1.96B 13.3B 5.17B 67.42B 5.26B 5.15B 223B
Net income -602M -516M -483M -442M -833M -57.68B -842M -5.72B -2.22B -28.97B -2.26B -2.21B -95.84B -326M -279M -261M -239M -451M -31.2B -456M -3.09B -1.2B -15.67B -1.22B -1.2B -51.84B
Net Debt -103M -88.24M -82.55M -75.47M -142M -9.86B -144M -977M -380M -4.95B -387M -378M -16.38B 57.45M 49.24M 46.06M 42.11M 79.47M 5.5B 80.32M 545M 212M 2.76B 216M 211M 9.14B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
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Global
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ESG MSCI
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