Valuation: Spyre Therapeutics, Inc.

Market Cap 10.35B 9.24B 8.5B 7.72B 14.62B 970B 14.99B 102B 40.54B 519B 38.85B 38.02B 1,636B P/E 2026 *
-34.4x
P/E 2027 * -27.8x
Enterprise Value 9.56B 8.53B 7.85B 7.12B 13.5B 896B 13.83B 93.88B 37.42B 479B 35.86B 35.1B 1,510B EV / Sales 2026 *
-
EV / Sales 2027 * -
Free-Float
93.91%
Yield 2026 *
-
Yield 2027 * -
1 day+4.95%
1 week+14.12%
Current month+12.88%
1 month+27.20%
3 months+3.90%
6 months+45.25%
Current year+232.72%
1 week 92.77
Extreme 92.77
110.64
1 month 76.87
Extreme 76.87
110.64
Current year 28
Extreme 28
110.64
1 year 21.63
Extreme 21.63
110.64
3 years 8.75
Extreme 8.75
110.64
5 years 2.66
Extreme 2.66
184.75
10 years 2.66
Extreme 2.66
300
Manager TitleAgeSince
Chief Executive Officer 36 27/11/2023
Director of Finance/CFO 49 01/09/2023
Chief Tech/Sci/R&D Officer - 27/11/2023
Director TitleAgeSince
Director/Board Member 36 27/11/2023
Director/Board Member 40 22/06/2023
Director/Board Member 36 22/06/2023
Date Insider Type Main position Quantity % Market Cap. Importance
01/10/26 Exercice

General Counsel

86,799 0.0984%
01/10/26 Exercice

Chief Financial Officer

22,500 0.0255%
01/10/26 Sell

Chief Executive Officer

-15,000 0.0170%
Change 5-day change 1-year change 3-year change Capi.($)
+4.95%+14.12%+384.01%+1,051.00% 10.35B
+2.24%+8.40%+58.47%+69.00% 68.22B
+0.68%+8.98%+15.35%+89.21% 59.82B
+0.74%+1.87%+24.42%+98.57% 56.07B
+2.55%+15.52%+30.43%+120.17% 47.67B
+2.58%+7.89%+32.49%+45.30% 45.95B
+4.09%+6.37%+228.06%+899.75% 43.29B
-0.47%+9.38%+27.53%+52.40% 35.66B
+0.44%-1.18%+95.95%+70.69% 34.73B
+1.48%+6.21%-38.80%+395.73% 25.47B
Average +1.93%+8.14%+85.79%+289.18% 43B
Weighted average by Cap. +1.73%+7.99%+61.78%+205.07%

Financials

2026 *2027 *
Net sales - -
Net income -296M -265M -244M -221M -419M -27.79B -429M -2.91B -1.16B -14.88B -1.11B -1.09B -46.86B -400M -357M -329M -298M -565M -37.5B -579M -3.93B -1.57B -20.08B -1.5B -1.47B -63.24B
Net Debt -797M -711M -654M -594M -1.13B -74.67B -1.15B -7.83B -3.12B -39.97B -2.99B -2.93B -126B -817M -729M -671M -609M -1.15B -76.57B -1.18B -8.03B -3.2B -40.99B -3.07B -3B -129B
Projected Income Statement - Annual - Spyre Therapeutics, Inc.
Logo Spyre Therapeutics, Inc.
Spyre Therapeutics, Inc. is a clinical-stage biotechnology company, specializing in long-acting antibodies and antibody combinations for inflammatory bowel disease (IBD) and rheumatic diseases. The Company's pipeline includes investigational extended half-life antibodies targeting a4b7, TL1A, and IL-23. It is advancing a pipeline of monoclonal antibodies (mAbs) for the treatment of IBD and other immune-mediated diseases. The Company's pipeline includes its SKYLINE Phase II platform trial evaluating SPY001, SPY002, SPY003, and pairwise combinations thereof in subjects with moderately to severely active UC and its SKYWAY basket trial evaluating SPY072 in three rheumatic diseases: rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA). SPY001 is a highly potent, highly selective, and humanized monoclonal immunoglobulin G1 investigational antibody designed to bind selectively to the a4b7 integrin being developed for the treatment of IBD (UC and CD).
Employees
130
Date Price Change Volume
09/11/26 $109.00 +4.95% 1,393,651
06/11/26 $103.86 +7.53% 1,635,370
05/11/26 $96.59 -2.47% 1,160,384
04/11/26 $99.04 -0.23% 1,495,489
03/11/26 $99.27 +3.94% 904,899
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
MarketScreener Ratings - Spyre Therapeutics, Inc.
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
18
Last Close Price
109.00USD
Average target price
122.27USD
Spread / Average Target
+12.17%
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