Valuation: Spyre Therapeutics, Inc.

Market Cap 8.98B 7.85B 7.26B 6.66B 12.6B 865B 12.82B 86.53B 33.99B 422B 33.71B 32.97B 1,458B P/E 2026 *
-33.2x
P/E 2027 * -30.2x
Enterprise Value 8.4B 7.34B 6.79B 6.23B 11.79B 809B 11.99B 80.94B 31.8B 395B 31.53B 30.84B 1,364B EV / Sales 2026 *
-
EV / Sales 2027 * -
Free-Float
89.17%
Yield 2026 *
-
Yield 2027 * -
1 day-4.62%
1 week+8.54%
Current month+12.66%
1 month+26.24%
3 months+64.81%
6 months+213.38%
Current year+224.82%
1 week 82
Extreme 82
89
1 month 72
Extreme 72
89
Current year 25.4
Extreme 25.4
89
1 year 12.3
Extreme 12.3
89
3 years 10.3
Extreme 10.3
89
5 years 10.3
Extreme 10.3
89
10 years 10.3
Extreme 10.3
89
Manager TitleAgeSince
Chief Executive Officer 36 27/11/2023
Director of Finance/CFO 49 01/09/2023
Chief Tech/Sci/R&D Officer - 27/11/2023
Director TitleAgeSince
Director/Board Member 36 27/11/2023
Director/Board Member 39 22/06/2023
Director/Board Member 36 22/06/2023
Change 5-day change 1-year change 3-year change Capi.($)
+2.89%+8.54% - - 8.98B
-3.42%+10.05%+58.59%+87.70% 57.82B
-0.05%-6.20%+55.97%+124.61% 53.71B
-2.14%-9.13%+2.74%+419.13% 23.8B
-0.47%-1.53%-18.61%-14.60% 23.26B
-0.56%+10.26%+44.03%-3.86% 20.7B
-0.29%-0.08%+38.91%-27.98% 17.81B
-4.55%-8.65%+194.32%+349.58% 16.9B
-2.61%+8.99%+46.11%+691.67% 16.36B
+0.23%-2.49%+24.26%+190.15% 13.96B
Average -1.85%+1.05%+49.59%+201.82% 27.15B
Weighted average by Cap. -1.72%+0.18%+49.14%+166.58%

Financials

2026 *2027 *
Net sales - -
Net income -273M -238M -220M -202M -383M -26.26B -389M -2.63B -1.03B -12.83B -1.02B -1B -44.28B -311M -272M -252M -231M -437M -30B -445M -3B -1.18B -14.65B -1.17B -1.14B -50.58B
Net Debt -580M -507M -469M -430M -814M -55.86B -828M -5.59B -2.2B -27.28B -2.18B -2.13B -94.18B -485M -424M -392M -360M -681M -46.72B -693M -4.67B -1.84B -22.82B -1.82B -1.78B -78.77B
Logo Spyre Therapeutics, Inc.
Spyre Therapeutics, Inc. is a clinical-stage biotechnology company, specializing in long-acting antibodies and antibody combinations for inflammatory bowel disease (IBD) and rheumatic diseases. The Company's pipeline includes investigational extended half-life antibodies targeting a4b7, TL1A, and IL-23. It is advancing a pipeline of monoclonal antibodies (mAbs) for the treatment of IBD and other immune-mediated diseases. The Company's pipeline includes its SKYLINE Phase II platform trial evaluating SPY001, SPY002, SPY003, and pairwise combinations thereof in subjects with moderately to severely active UC and its SKYWAY basket trial evaluating SPY072 in three rheumatic diseases: rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA). SPY001 is a highly potent, highly selective, and humanized monoclonal immunoglobulin G1 investigational antibody designed to bind selectively to the a4b7 integrin being developed for the treatment of IBD (UC and CD).
Employees
112
Date Price Change
16/07/26 89.00 +2.89%
15/07/26 €86.50 +5.49%
14/07/26 €82.00 -3.53%
13/07/26 €85.00 -1.16%
10/07/26 €86.00 +2.99%
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
17
Last Close Price
102.07USD
Average target price
103.93USD
Spread / Average Target
+1.83%

Quarterly revenue - Rate of surprise