Valuation : Ionis Pharmaceuticals, Inc.

Market Cap 9.31B 8.01B 7.55B 6.88B 12.86B 890B 12.98B 89.97B 34.63B 451B 34.96B 34.2B 1,434B P/E 2026 *
-15.4x
P/E 2027 * -29.8x
Enterprise Value 9.21B 7.92B 7.47B 6.81B 12.72B 880B 12.84B 88.97B 34.24B 446B 34.57B 33.82B 1,418B EV / Sales 2026 *
10.1x
EV / Sales 2027 * 6.78x
Free-Float
99.05%
Yield 2026 *
-
Yield 2027 * -
1 day-0.87%
1 week-4.51%
Current month-8.04%
1 month-2.51%
3 months-24.29%
6 months-26.63%
Current year-29.83%
1 week 52.15
Extreme 52.15
58.96
1 month 52.15
Extreme 52.15
64.19
Current year 50
Extreme 50.005
86.74
1 year 50
Extreme 50.005
86.74
3 years 23.95
Extreme 23.95
86.74
5 years 23.95
Extreme 23.95
86.74
10 years 23.95
Extreme 23.95
86.74
Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Date Insider Type Main position Quantity % Market Cap. Importance
31/08/26 Others

Chief Technology Officer

110 0.0001%
31/08/26 Others

Executive/Senior Manager

58 0.0000%
31/08/26 Others

Founder

98 0.0001%
Change 5-day change 1-year change 3-year change Capi.($)
-0.87%-4.51%-13.27%+34.44% 9.31B
-0.56%-8.08%-3.88%+9.81% 46.38B
-1.49%-2.97%+405.81%+522.45% 44.51B
+0.38%-4.92%+40.46%+19.94% 42.3B
-2.50%-5.55%+9.11%+63.71% 39.91B
-1.26%-2.95%+12.00%+40.55% 32.79B
-0.09%-3.85% - - 17.13B
-0.05%-1.20%+22.98%+109.86% 16.36B
-0.03%-3.46%+12.68%+30.90% 14.31B
-1.84%-6.78%+78.41%+36.96% 13.29B
Average -0.84%-3.64%+62.70%+96.51% 27.63B
Weighted average by Cap. -0.92%-3.43%+84.23%+121.46%

Financials

2026 *2027 *
Net sales 913M 785M 741M 675M 1.26B 87.26B 1.27B 8.82B 3.39B 44.26B 3.43B 3.35B 141B 1.38B 1.19B 1.12B 1.02B 1.91B 132B 1.93B 13.36B 5.14B 67.03B 5.19B 5.08B 213B
Net income -584M -502M -474M -431M -807M -55.81B -814M -5.64B -2.17B -28.31B -2.19B -2.14B -89.91B -314M -270M -255M -232M -434M -30.06B -438M -3.04B -1.17B -15.25B -1.18B -1.15B -48.42B
Net Debt -103M -88.57M -83.57M -76.13M -142M -9.85B -144M -995M -383M -4.99B -387M -378M -15.86B 68.31M 58.74M 55.43M 50.49M 94.39M 6.53B 95.25M 660M 254M 3.31B 257M 251M 10.52B
Logo Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
1,480
Date Price Change Volume
10/09/26 $55.52 -0.89% 1,199,475
09/09/26 $56.02 -1.22% 3,037,757
08/09/26 $56.71 -2.38% 9,175,745
04/09/26 $58.09 -0.07% 2,671,092
03/09/26 $58.13 -5.22% 4,347,907
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
A
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
24
Last Close Price
56.02USD
Average target price
84.23USD
Spread / Average Target
+50.35%

Quarterly revenue - Rate of surprise

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