Valuation: Ionis Pharmaceuticals, Inc.

Market Cap 9.01B 7.81B 7.37B 6.68B 12.54B 863B 12.63B 87.98B 33.9B 438B 33.84B 33.09B 1,393B P/E 2026 *
-14.9x
P/E 2027 * -28.8x
Enterprise Value 8.91B 7.72B 7.28B 6.61B 12.39B 854B 12.48B 86.97B 33.51B 433B 33.45B 32.71B 1,377B EV / Sales 2026 *
9.76x
EV / Sales 2027 * 6.57x
Free-Float
99.05%
Yield 2026 *
-
Yield 2027 * -
1 day-5.19%
1 week-9.14%
Current month-14.64%
1 month-9.98%
3 months-30.33%
6 months-28.77%
Current year-34.87%
1 week 51.39
Extreme 51.39
57.43
1 month 51.39
Extreme 51.39
64.19
Current year 50
Extreme 50.005
86.74
1 year 50
Extreme 50.005
86.74
3 years 23.95
Extreme 23.95
86.74
5 years 23.95
Extreme 23.95
86.74
10 years 23.95
Extreme 23.95
86.74
Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Date Insider Type Main position Quantity % Market Cap. Importance
31/08/26 Others

Chief Technology Officer

110 0.0001%
31/08/26 Others

Executive/Senior Manager

58 0.0000%
31/08/26 Others

Founder

98 0.0001%
Change 5-day change 1-year change 3-year change Capi.($)
-5.00%-9.14%-15.67%+18.07% 9.01B
+0.56%-4.71%-2.38%+9.18% 45.48B
+0.60%-0.65%+345.84%+532.81% 43.68B
+1.51%+2.18%+42.43%+24.38% 43.09B
+2.01%+0.78%+6.60%+78.44% 39.4B
+0.34%-4.94%+9.34%+40.23% 31.91B
+0.48%-3.00% - - 17.31B
+1.25%+0.26%+19.34%+111.55% 16.4B
+2.07%-0.77%+13.07%+32.89% 14.24B
-1.96%-3.42%+78.12%+30.52% 13.28B
Average +0.24%-3.34%+55.19%+97.56% 27.38B
Weighted average by Cap. +0.81%-3.37%+73.23%+124.68%

Financials

2026 *2027 *
Net sales 913M 791M 746M 677M 1.27B 87.48B 1.28B 8.91B 3.43B 44.38B 3.43B 3.35B 141B 1.38B 1.2B 1.13B 1.03B 1.92B 132B 1.94B 13.5B 5.2B 67.21B 5.19B 5.08B 214B
Net income -584M -506M -477M -433M -812M -55.95B -818M -5.7B -2.2B -28.38B -2.19B -2.14B -90.23B -314M -272M -257M -233M -437M -30.13B -441M -3.07B -1.18B -15.29B -1.18B -1.15B -48.6B
Net Debt -103M -89.24M -84.22M -76.4M -143M -9.87B -144M -1.01B -388M -5.01B -387M -378M -15.92B 68.31M 59.19M 55.86M 50.67M 95.06M 6.55B 95.75M 667M 257M 3.32B 257M 251M 10.56B
Logo Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
1,480
Date Price Change Volume
14/09/26 $51.58 -4.85% 3,777,719
11/09/26 $54.21 -2.59% 2,175,778
10/09/26 $55.65 -0.66% 3,057,309
09/09/26 $56.02 -1.22% 3,037,757
08/09/26 $56.71 -2.38% 9,175,745
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
A
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
24
Last Close Price
54.21USD
Average target price
84.23USD
Spread / Average Target
+55.37%

Quarterly revenue - Rate of surprise

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