Valuation: Silence Therapeutics plc

Market Cap 886M 1.18B 1.06B 975M 1.66B 112B 1.69B 11.75B 4.63B 58.77B 4.45B 4.35B 186B P/E 2026 *
-38.5x
P/E 2027 * -31.7x
Enterprise Value 752M 1B 897M 827M 1.41B 95.17B 1.43B 9.97B 3.93B 49.86B 3.77B 3.69B 158B EV / Sales 2026 *
2,286x
EV / Sales 2027 * 934x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -
1 day-0.05%
1 week+110.27%
Current month+79.87%
1 month+59.97%
3 months+66.19%
6 months+146.68%
Current year+223.36%
1 week 19.56
Extreme 19.56
19.69
1 month 8.66
Extreme 8.66
19.69
Current year 4.19
Extreme 4.19
19.69
1 year 4.19
Extreme 4.19
19.69
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 01/12/2025
Director of Finance/CFO 54 01/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/01/2004
Director/Board Member 65 05/05/2025
Date Insider Type Main position Quantity % Market Cap. Importance
06/07/26 Sell 865,112 0.6105%
02/01/26 Free

Chief Financial Officer

375,000 0.2646%
02/01/26 Free

Director

90,000 0.0635%
Change 5-day change 1-year change 3-year change Capi.($)
-0.05%+110.27%+173.06%+175.74% 1.18B
-4.10%-8.54%+40.05%+66.99% 63.29B
+0.59%+8.30%+11.84%+74.76% 54.89B
+0.64%+4.67%+10.14%+92.98% 53.28B
+0.61%+2.69%+27.75%+50.97% 45.81B
-1.08%+2.19%+21.92%+131.38% 43.46B
-3.39%-0.83%+254.27%+571.04% 40.23B
-1.67%+6.70%+14.42%+56.67% 33.45B
+1.19%-4.98%+29.01%-0.76% 23.7B
-0.30%+5.68%+36.43%+27.54% 23.76B
Average -0.76%+11.44%+61.89%+124.73% 38.31B
Weighted average by Cap. -1.00%+0.93%+48.08%+122.84%

Financials

2026 *2027 *
Net sales 329K 439K 392K 362K 617K 41.62M 626K 4.36M 1.72M 21.81M 1.65M 1.61M 69.09M 760K 1.02M 907K 837K 1.43M 96.28M 1.45M 10.08M 3.97M 50.44M 3.82M 3.73M 160M
Net income -42.57M -56.9M -50.79M -46.86M -79.87M -5.39B -81.09M -565M -222M -2.82B -214M -209M -8.95B -64.86M -86.69M -77.38M -71.39M -122M -8.21B -124M -860M -339M -4.3B -325M -318M -13.63B
Net Debt -134M -180M -160M -148M -252M -17.01B -256M -1.78B -702M -8.91B -674M -660M -28.24B -176M -235M -210M -193M -330M -22.26B -335M -2.33B -918M -11.66B -882M -863M -36.94B
Projected Income Statement - Annual - Silence Therapeutics plc
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
22/10/26 $19.66 -0.05% 3,078,639
21/10/26 $19.67 +0.31% 2,801,618
20/10/26 $19.61 +0.15% 13,962,894
19/10/26 $19.58 +125.58% 71,918,759
16/10/26 $8.680 -7.17% 1,131,128
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
MarketScreener Ratings - Silence Therapeutics plc
Sell
Consensus
Buy
Mean consensus
OUTPERFORM
Number of Analysts
5
Last Close Price
19.66USD
Average target price
19.75USD
Spread / Average Target
+0.46%

Quarterly revenue - Rate of surprise

Rate of surprise - Net sales - Quarterly - Silence Therapeutics plc