Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 10.31B 8.84B 8.27B 7.56B 14.26B 987B 14.41B 97.81B 38.03B 496B 38.71B 37.87B 1,640B P/E 2026 *
-17x
P/E 2027 * -32.8x
Enterprise Value 10.21B 8.75B 8.18B 7.48B 14.12B 977B 14.27B 96.83B 37.65B 491B 38.32B 37.49B 1,624B EV / Sales 2026 *
11.2x
EV / Sales 2027 * 7.39x
Free-Float
99.05%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 10.31B
-0.74%+3.78%+3.74%+23.10% 51.21B
+1.01%-0.20%+471.68%+564.93% 45.35B
+0.16%+7.88%+36.14%+20.76% 42.84B
-0.66%+2.61%+18.59%+87.04% 42.29B
+0.88%-3.48%+17.20%+53.83% 32.15B
-0.12%+3.84%+33.73%+145.25% 17.31B
-0.53%+1.84% - - 16.55B
+0.58%+4.66%+7.17%+30.87% 14.84B
+1.15%+4.17%+84.49%+50.33% 14.25B
Average +0.31%+3.23%+84.09%+122.01% 30.75B
Weighted average by Cap. +0.15%+3.07%+101.31%+141.38%

Financials

2026 *2027 *
Net sales 913M 783M 732M 670M 1.26B 87.46B 1.28B 8.67B 3.37B 43.92B 3.43B 3.36B 145B 1.4B 1.2B 1.12B 1.03B 1.94B 134B 1.96B 13.3B 5.17B 67.42B 5.26B 5.15B 223B
Net income -602M -516M -483M -442M -833M -57.68B -842M -5.72B -2.22B -28.97B -2.26B -2.21B -95.84B -326M -279M -261M -239M -451M -31.2B -456M -3.09B -1.2B -15.67B -1.22B -1.2B -51.84B
Net Debt -103M -88.24M -82.55M -75.47M -142M -9.86B -144M -977M -380M -4.95B -387M -378M -16.38B 57.45M 49.24M 46.06M 42.11M 79.47M 5.5B 80.32M 545M 212M 2.76B 216M 211M 9.14B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
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